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KMID : 0608519990050010111
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Korean Journal of Oriental Medicine
1999 Volume.5 No. 1 p.111 ~ p.117
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Protective effects of Chungpesagan-tang against ischemia/reperfusion induced cell injury
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Hong Seong-Gil
Kang Bong-Joo
Kim Yun-Jin
Kang Sang-Mo
Cho Dong-Wuk
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Abstract
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Free radicals are thought to be the most important cause of the reperfusion injury subsequent to ischemia. The antioxidant status of the tissue affected by ischemia-reperfusion is of great importance for the primary endogenous defense against the free radical induced injury. Therefore, antioxidant therapy has been shown to be beneficial in neurological disorders such as Alzheimer’s disease and cerebral ischemia. In this study, the protective effects of Chungpesagan-tang (CST) was investigated against ischemia/reperfusion-induced cytotoxicity in SK-N-MC neuronal cells It was found out that low concentration of CST was highly effective in protecting neuronal cells against ischemia/reperfusion-induced cytotoxicity. The inhibitory effect of CST on malondialdehyde formation during ischemia/reperfusion-induced oxidative stress in SK-N-MC cells showed obvious dose-dependent responses. Also, CST showed relatively high inhibitory activity to xanthine oxidase induced by ischemia/reperfusion environment Therefore, it is thought that CST has both antioxidant and xanthine oxidase inhibitory effect and can be used for clinical applications for protection of neuronal cells from ischemia-reperfusion injury.
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KEYWORD
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Korea traditional prescription, Lipid peroxidation, Free radical, Ischemia, Xanthine oxidase
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